Summit Highlights Utrophin Modulation as a Potential Universal Treatment Option in DMD at Action Duchenne Nasdaq:SMMT: "Summit Therapeutics plc (NASDAQ: SMMT, AIM: SUMM) the drug discovery and development company advancing therapies for Duchenne muscular dystrophy ('DMD') and Clostridium difficile infection, announces that the Company and collaborators from the University of Oxford will highlight the potential of utrophin modulation as a universal treatment for DMD in several presentations at the 15th Action Duchenne International Conference 2017, taking place November 10-12, 2017, in Birmingham, UK. The conference brings together families living with Duchenne and Becker muscular dystrophy, along with experts and industry members aiming to treat these diseases.
The Company's scientific adviser and co-founder, Professor Kay Davies from the University of Oxford, will present recently published preclinical data highlighting the benefits of utrophin modulation on muscle health in animal models of DMD. The data show that continuously expressing utrophin in a dystrophin-deficient background can reduce mitochondrial aberration and oxidative stress. Aberrant mitochondria drive, in part, oxidative stress, which is a contributing factor to muscle damage in DMD. In addition, Professor Davies is also expected to discuss previously published preclinical data of utrophin modulators, including ezutromid, that have shown these compounds' potential to prevent molecular disease, leading to functional improvements in mdx mice."
'via Blog this'
No comments:
Post a Comment