Cell therapy for heart disease caused by muscular dystrophy also improves limb strength, study shows: "Injections of cardiac progenitor cells help reverse the fatal heart disease caused by Duchenne muscular dystrophy and also lead to improved limb strength and movement ability, a new study shows.
The study, published today in Stem Cell Reports, showed that when researchers injected cardiosphere-derived cells (CDCs) into the hearts of laboratory mice with muscular dystrophy, heart function improved along with a marked increase in exercise capacity.
"We unexpectedly found that treating the heart made the whole body better," said Eduardo Marbán, MD, PhD, director of the Smidt Heart Institute and the investigator who developed the cardiosphere-derived cell technology used in the study. "These basic findings, which have already been translated to clinical trials, rationalize why treating the heart may also benefit skeletal muscle function in boys and young men with Duchenne.""
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